Atheroma: a new hypothesis.

A new cancer hypothesis.

Despite intensive efforts to cure breast cancer, treatment generally fails, as evidenced by the age-adjusted mortality rate for breast cancer. For 60 years, breast cancer mortality remained virtually constant. As treatment failed to improve the life prospect of the average patient, it is based on false premises, e.g. Halsted's hypothesis, according to which the tumor is the only threat to the p...

Metronomic Effect as A New Hypothesis in Maintenance Therapy of Acute Lymphoblastic Leukemia

A new hypothesis for dystonia.

In this issue of the Annals, Goto and colleagues present a new hypothesis concerning the pathophysiology of dystonia. A measure of our limited understanding of dystonias is the fact that although dystonia is a brain disorder, the most effective treatment is botulinum toxin chemodenervation at the neuromuscular junction. Ignorance of the mechanisms of dystonia is an obstacle to developing mechan...

A New Hypothesis on Compositionality

In this paper we put forward a new hypothesis on compositionality of meaning, namely that compositionality is bidirectional optimization. Underspecification approaches to natural language interpretation generally start with an underspecified or weak meaning, which is strengthened by contextual information. In contrast, the bidirectional optimization approach we advocate proceeds from the strong...

A new hypothesis of drug refractory epilepsy: neural network hypothesis.

Drug refractory is an important clinical problem in epilepsy, affecting a substantial number of patients globally. Mechanisms underlying drug refractory need to be understood to develop rational therapies. Current two prevailing theories on drug refractory epilepsy (DRE) include the target hypothesis and the transporter hypothesis. However, those hypotheses could not be adequate to explain the ...